Can I cruise if I have mixed vaccine doses? That’s a question we’ve been getting a lot lately. And up until recently, there wasn’t a clear answer.
This was particularly alarming to Canadian cruisers whose country has been mixing vaccine doses. But over the past couple of months, cruise lines have been updating health protocols to let cruisers know what vaccine they need to cruise.
Below is a guide by cruise line, detailing what vaccines they accept and what they consider as fully vaccinated in North America. Note that each cruise line requirements may vary depending on the ports of call or where they are sailing from.
Currently, cruise operators are using guidance from the U.S. Food and Drug Administration, World Health Organization (WHO), and the European Medicines Agency (EMA) to determine which vaccines are approved.
The full brand vaccination protocol of one brand of vaccine or two doses of a mixed vaccination combination must be completed at least 14 days before the sailing date.
Azamara
Accepted Non-Mixed Vaccines: Vaccines that are fully approved or authorized for emergency use by the Food and Drug Administration (FDA) or the European Medicines Agency (EMA)
Accepted Mixed Vaccines: Mixed doses of Pfizer and Moderna mRNA vaccines, as well as those that include AstraZeneca as long as the AstraZeneca shot is administered first, followed by either Pfizer or Moderna within 8-12 weeks
Carnival Cruise Line
Accepted Non-Mixed Vaccines: Vaccines that are fully approved or authorized for emergency use by the Food and Drug Administration or the World Health Organization (WHO)
Accepted Mixed Vaccines: Those who have received a combination of two doses of an authorized/approved vaccine such as AstraZeneca (1 dose) and either Pfizer (1 dose) or Moderna (1 dose)

Celebrity Cruises
Accepted Non-Mixed Vaccines: Vaccines that are fully approved or authorized for emergency use by the Food and Drug Administration or the World Health Organization are accepted. U.S.-based AstraZeneca and Novavax clinical trial participants are also considered fully vaccinated.
Accepted Mixed Vaccines: For all sailings around the world, a mix of any two of these vaccines are accepted with a minimum of 28 days between doses: Pfizer, Moderna, AstraZeneca, Sinovac, and Sinopharm. Those who received the Johnson & Johnson shot before or after another vaccine should be considered to have had a single dose of Johnson & Johnson — not a mixed vaccine series — and are considered fully vaccinated.
Disney Cruise Line
Accepted Non-Mixed Vaccines: Those produced by Pfizer, Moderna, AstraZeneca, and Johnson & Johnson
Accepted Mixed Vaccines: Mixed doses of Moderna (1 dose) and Pfizer (1 dose)
MORE: 8 Tips For Preparing to Cruise in 2021
Holland America Line
Accepted Non-Mixed Vaccines: Vaccines that are fully approved or authorized for emergency use by the Food and Drug Administration or the World Health Organization are accepted. Novavax clinical trial participants who received the full 2-dose series are also considered fully vaccinated.
Accepted Mixed Vaccines: Mixed doses of Moderna (1 dose) and Pfizer (1 dose), or mixed doses of AstraZeneca (1 dose) and either Pfizer (1 dose) or Moderna (1 dose)

MSC Cruises
Accepted Non-Mixed Vaccines: Vaccines that are approved by the World Health Organization, which includes Pfizer, Moderna, Johnson & Johnson, and AstraZeneca/Covidshield
Accepted Mixed Vaccines: Mixed vaccines are not accepted.
Norwegian Cruise Line
Accepted Non-Mixed Vaccines: Vaccines that are fully approved or authorized for emergency use by the Food and Drug Administration, the World Health Organization, and/or the European Medicines Agency
Accepted Mixed Vaccines: A mixed vaccination combination of two doses of an FDA approved/authorized or WHO Emergency Use Listed two-dose series with a minimum interval of 17 days are accepted. Those who received the Johnson & Johnson shot before or after another vaccine should be considered to have had a single dose of Johnson & Johnson — not a mixed vaccine series — and are considered fully vaccinated.
Oceania Cruises
Accepted Non-Mixed Vaccines: Vaccines that are fully approved or authorized for emergency use by the Food and Drug Administration and/or the World Health Organization (WHO)
Accepted Mixed Vaccines: Mixed doses of Moderna (1 dose) and Pfizer (1 dose) with a minimum interval of 28 days

Princess Cruises
Accepted Non-Mixed Vaccines: Vaccines that are fully approved or authorized for emergency use by the Food and Drug Administration or the World Health Organization are accepted. Novavax clinical trial participants who received the full 2-dose series are also considered fully vaccinated.
Accepted Mixed Vaccines: Mixed doses of Moderna (1 dose) and Pfizer (1 dose), or mixed doses of AstraZeneca (1 dose) and either Pfizer (1 dose) or Moderna (1 dose)
Regent Seven Seas Cruises
Accepted Non-Mixed Vaccines: Vaccines that are fully approved or authorized for emergency use by the Food and Drug Administration, the World Health Organization, and/or the European Medicines Agency
Accepted Mixed Vaccines: A mixed vaccination combination of two doses of an FDA or EMA approved/authorized or WHO Emergency Use Listed two-dose series with a minimum interval of 17 days are accepted. Those who received the Johnson & Johnson shot before or after another vaccine should be considered to have had a single dose of Johnson & Johnson — not a mixed vaccine series — and are considered fully vaccinated.
Royal Caribbean
Accepted Non-Mixed Vaccines: Vaccines that are fully approved or authorized for emergency use by the Food and Drug Administration or the World Health Organization
Accepted Mixed Vaccines: A mixed series of mRNA vaccines, such as Pfizer (1 dose) and Moderna (1 dose) administered a minimum of 28 days apart
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Note: These vaccine protocols are subject to change at any time. Check with your cruise line for the latest up-to-date guidance.
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